Galectin-1: Oligomeric Structure and Interactions with Polylactosamine.
نویسندگان
چکیده
منابع مشابه
Dimeric Galectin-8 induces phosphatidylserine exposure in leukocytes through polylactosamine recognition by the C-terminal domain.
Human galectins have distinct and overlapping biological roles in immunological homeostasis. However, the underlying differences among galectins in glycan binding specificity regulating these functions are unclear. Galectin-8 (Gal-8), a tandem repeat galectin, has two distinct carbohydrate recognition domains (CRDs) that may cross-link cell surface counter receptors. Here we report that each Ga...
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Four generations of lactose-functionalized polyamidoamine (PAMAM) were employed to further the understanding of multivalent galectin-1 mediated interactions. Dynamic light scattering and fluorescence microscopy were used to study the multivalent interaction of galectin-1 with the glycodendrimers in solution, and glycodendrimers were observed to organize galectin-1 into nanoparticles. In the pre...
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Eklund et al., 1976). Models of the alkylcyclohexanols formed as products were placed into the active-site pocket such that their hydroxyl oxygen atom appears in the position where the water oxygen atom was observed in the apoenzyme. Within the freedom of motion allowed by the geometric constraints of the active-site pocket the alkylcyclohexanol models were allowed to change their orientation. ...
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ژورنال
عنوان ژورنال: Trends in Glycoscience and Glycotechnology
سال: 1997
ISSN: 0915-7352,1883-2113
DOI: 10.4052/tigg.9.47